I've read social biological theories that men are hard-wired to be promiscuous, because the species (back in the day) was more likely to spread and thrive with multiple partners. Women can only give birth to one set of young at a time, but men, built to travel, can have virtually unlimited progeny.
The theory doesn't forgive cheating, by the way, it just says that part of being civilized is clamping down on some of our less desirable biological urges. It also talked about the biology of "chemistry" that attracts us, holds us for a couple of years to mate, then at the "7 yr itch" period, not only wears off but points us in different directions.